Magnetic bead chemiluminescence enzyme immunoassay is an integrated detection technology that integrates magnetic bead separation technology, sensitive chemiluminescence analysis and specific antigen-antibody immunoassay. The bound state (complex: enzyme-labeled antibody + target antigen + magnetic particle antibody) is separated from the non-target substance and enzyme-labeled antibody in the free state by a magnetic field, and a luminescent substrate is added to perform a luminescence reaction, and the luminescence intensity is detected or qualitative determination.
Therefore, magnetic beads are a reusable substance. After the detection is completed, in the process of waste liquid treatment, the treatment of magnetic beads is particularly important. A mature chemiluminescence manufacturer will choose high-performance peristaltic pumps as waste disposal. liquid solution.
A well-known international manufacturer of chemiluminescence instruments chooses twelve single-channel peristaltic pumps for draining waste liquid. The first consideration is its independent control system. The 12 pumps can independently control the start and stop and flow. The second is the long life of the pump. Thanks to the patented planetary gear pump head structure, it is nearly twice as long as the hose life of the general peristaltic pump. It only takes 1-2 years to replace the hose. On this basis, there is a pump head assembly module, which can be replaced just like screwing a bottle cap.
In this era of in vitro diagnostic instruments blooming, each company has different instruments, and each company has its own form in the layout of the liquid circuit, some are single-channel, some are multi-channel, and multi-channel OEM pump products can be provided to customers More choices. Considering the cost and the disassembly between the tube cards, a maximum of 8 channels for one motor can be achieved to meet customer space and cost requirements.
Thanks to the structure of the peristaltic pump, compared with the diaphragm pump, the target liquid does not pass through the pump cavity, and all processes are completed within the hose, and a small amount of magnetic beads will not block the pump body, resulting in decreased flow performance.
In chemiluminescence detection, the handling of magnetic beads is particularly important. If only the speed is pursued, the magnetic beads in the mixed waste liquid may be sucked away. Compared with pumps with other structures, the single-multi-channel peristaltic pump solution has been chosen by many manufacturers, which can not only pump the waste liquid in a short time, but also greatly retain the magnetic bead content in the waste liquid.
